Wayne Memorial Drive will be closed between Hare Road and Stoney Creek Church Road starting Monday.
A detour will send motorists to Tommy's and Hare roads.
The road is being closed for a project that includes installing a culvert.
The N.C. Department of Transportation earlier awarded a $2.6 million contract this year to S.T. Wooten Corp. of Wilson to replace a drainage pipe with a more durable concrete, box-shaped culvert underneath the road.
The road is scheduled to reopen by mid-August before the schools are back in session.
Under the contract, crews will also resurface and widen the existing lanes of Wayne Memorial Drive between Woodside Drive and Saulston Road, a distance of 2.4 miles.
That work will be completed by the fall.